Invited Talk: Deciphering Gene Regulatory Networks by in silico approaches

Biological processes are controlled at various levels in the celland while these mechanisms are poorly understood, tran-
scriptional control is widely recognized as an important com-
ponent and a better understanding of which will provide an
efficient means for the therapeutic intervention in disease
processes. We have been focusing on various computational
problems pertaining to transcriptional regulation, namely,
(1) representation and identification of transcription factor
binding sites,(2) PolII promoter prediction,(3) Predicting
interaction among transcription factors,(4) Transcriptional
modeling, ie identifying arrangements of TFs that co-
regulate a set of transcripts. I will present a brief overview
of the computational approaches and challenges as well as a
number of applications including transcriptional regulation
in memory storage, heart failure, and osteoarthritis.